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論文名 著者名 発表誌名
Visit-to-visit variability in systolic blood pressure predicts development and progression of diabetic nephropathy, but not retinopathy, in patients with type 2 diabetes T. Takao,
Y. Matsuyama,
H. Yanagisawa,
M. Kikuchi,
S. Kawazu		 J Diabetes Complications. 28:185－190, 2014
Published online: 18 November, 2013
DOI
Superior glycaemic control with once-daily insulin degludec/insulin aspart versus insulin glargine in Japanese adults with type 2 diabetes inadequately controlled with oral drugs: a randomized, controlled phase 3 trial Y. Onishi,
Y. Ono,
R. Rabol,
L. Endahl,
S. Nakamura		 Diabetes Obes Metab. 15: 826－832, 2013
Article first published online: 5 APR 2013
DOI
Insulin degludec compared with insulin glargine in insulin-naive patients with type 2 diabetes: A 26-week, randomized, controlled, Pan-Asian, treat-to-target trial Y. Onishi,
Y. Iwamoto,
SJ. Yoo,
P. Clauson,
SC. Tamer,
S. Park		 J Diabetes Invest 4: 605－612, 2013
Article first published online: 3 JUN 2013
DOI
Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development. A. Kushiyama,
H. Sakoda,
N. Oue,
M. Okubo,
Y. Nakatsu,
H. Ono,
T. Fukushima,
H. Kamata,
F. Nishimura,
T. Kikuchi,
M. Fujishiro,
K. Nishiyama,
H. Aburatani,
S. Kushiyama,
M. Iizuka,
N. Taki,
J. Encinas,
K. Sentani,
N. Ogonuki,
A. Ogura,
S. Kawazu,
W. Yasui,
Y. Higashi,
H. Kurihara,
H. Katagiri,
T. Asano 		Arterioscler Thromb Vasc Biol. 33:1986－1993, 2013
DOI
Twenty year trend of increasing obesity in young patients with poorly controlled type 2 diabetes at?first diagnosis in urban Japan A. Kushiyama,
Y. Yoshida,
T. Kikuchi,
N. Suzawa,
M. Yamamoto,
K. Tanaka,
T. Tahara,
T. Takao,
Y. Onishi,
S. Kawazu		 J Diabetes Invest. 4: 540－545, 2013
DOI
Serum butyrylcholinesterase and the risk of future type 2 diabetes: the Kansai Healthcare Study. （共同研究）
KK. Sato,
T. Hayashi,
I. Maeda,
H. Koh,
N. Harita,
S. Uehara,
Y. Onishi,
K. Oue,
Y. Nakamura,
G. Endo,
H. Kambe,
K.Fukuda 		Clin Endocrinol (Oxf). 80:362－367, 2014　Article first published online: 20 MAY, 2013
DOI
Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice. （共同研究）
M. Iwashita,
Y. Nakatsu,
H. Sakoda,
M. Fujishiro,
A. Kushiyama,
T. Fukushima,
S. Kumamoto,
T. Shinjo,
H. Kamata,
F. Nishimura,
T. Asano		 Adipocyte. 2:28－32, 2013
PubMed
Integrator complex plays an essential role in adipose differentiation. （共同研究）
Y. Otani,
Y. Nakatsu,
H. Sakoda,
T. Fukushima,
M. Fujishiro,
A. Kushiyama,
H. Okubo,
Y. Tsuchiya,
H. Ohno,
S. Takahashi,
F. Nishimura,
H. Kamata,
H. Katagiri,
T. Asano		 Biochem Biophys Res Commun. 434:197－202, 2013
DOI
Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions. （共同研究）
J. Zhang,
Y. Nakatsu,
T. Shinjo,
Y. Guo,
H. Sakoda,
T. Yamamotoya,
Y. Otani,
H. Okubo,
A. Kushiyama,
M. Fujishiro,
T. Fukushima,
Y. Tsuchiya,
H. Kamata,
M. Iwashita,
F. Nishimura,
H. Katagiri,
S. Takahashi,
H. Kurihara,
T. Uchida,
T. Asano		 J Biol Chem. 288:20692－20701, 2013
DOI
The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease. （共同研究）
A. Hashikata,
A. Yamashita,
S. Suzuki,
S. Nagayasu,
T. Shinjo,
A. Taniguchi,
M. Fukushima,
Y. Nakai,
K. Nin,
N. Watanabe,
T. Asano,
Y. Abiko,
A. Kushiyama,
S. Nagasaka,
F. Nishimura 		Nephrol Dial Transplant. First published online: November 13, 2013
DOI
Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model. （共同研究）
H. Okubo,
H. Sakoda,
A. Kushiyama,
M. Fujishiro,
Y. Nakatsu,
T. Fukushima,
Y. Matsunaga,
H. Kamata,
T. Asahara,
Y. Yoshida,
O. Chonan,
M. Iwashita,
F. Nishimura,
T. Asano		 Am J Physiol Gastrointest Liver Physiol. 305:G911－G918，2013
DOI
Leisure-time physical activity is a significant predictor of stroke and total mortality in Japanese patients with type 2 diabetes: analysis from the Japan Diabetes Complications Study (JDCS) （共同研究）
H. Sone,
S. Tanaka,
S. Tanaka,
S. Suzuki,
H. Seino,
O. Hanyu,
A. Sato,
T. Toyonaga,
K. Okita,
S. Ishibashi,
S. Kodama,
Y. Akanuma,
N. Yamada; Japan Diabetes Complications Study Group.		 Diabetologia 56:1021－1030, 2013
DOI
The long-term coronary heart disease risk of previously obese patients with type 2 diabetes melitus （共同研究）
R. Yamamoto-Honda,
H. Ehara,
H. Kitazato,
Y. Takahashi,
S. Kawazu,
Y. Akanuma,
M. Noda		 BMC Endocr Disord. 13:38, 2013
DOI
＜症例報告＞
胃潰瘍の出血により急性高心拍出量性心不全を呈した高齢者大球性貧血の一例		 松﨑 弦，
芦田映直，
赤沼真夫，
藤井 潤，
世古義規		 日本老年医学会雑誌 50：409－412, 2013
J-STAGE
Heat shock factor 1 accelerates hepatocellular carcinoma development by activating nuclear factor κB/mitogen-activated protein kinase M. Chuma,
N. Sakamoto,
A. Nakai,
S. Hige,
M. Nakanishi,
M. Natsuizaka,
G. Suda,
T. Sho,
K. Hatanaka,
Y. Matsuno,
H. Yokoo,
T. Kamiyama,
A. Taketomi,
G. Fujii,
K. Tashiro,
Y. Hikiba,
M. Fujimoto,
M. Asaka,
S. Maeda		 Carcinogenesis. 35:272－278，2014
First published online: October 15, 2013
DOI
MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression. （共同研究）
A. Takata,
M. Otsuka,
T. Yoshikawa,
T. Kishikawa,
Y. Hikiba,
S. Obi,
T. Goto,
YJ. Kang,
S. Maeda,
H. Yoshida,
M. Omata,
H. Asahara,
K. Koike 		Hepatology. 57:162－170, 2013
DOI
Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis. （共同研究）
H. Kinoshita,
Y. Hirata,
H. Nakagawa,
K. Sakamoto,
Y. Hayakawa,
R. Takahashi,
W. Nakata,
K. Sakitani,
T. Serizawa,
Y. Hikiba,
M. Akanuma,
W. Shibata,
S. Maeda,
K. Koike		 PLoS One. 8:e60914, 2013
Published online: Apr 12, 2013
DOI
論文名 著者名 発表誌名
Safety of exenatide once weekly for 52 weeks in Japanese patients with type 2 diabetes mellitus. Y. Onishi,
H. Koshiyama,
T. Imaoka,
H. Haber,
J. Scism-Bacon,
MK. Boardman		 J Diabetes Invest Article first published online: 22 OCT 2012
PubMed
Influence of Helicobacter pylori Eradication on the Management of Type 2 Diabetes. M. Akanuma,
A. Yanai,
K. Sakamoto,
Y. Hirata,
Y. Yamaji,
S. Kawazu,
S. Maeda		 Hepatogastroenterology 59: 641－645, 2012
PubMed
Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli. K. Sakamoto,
Y. Hikiba,
H. Nakagawa,
Y. Hirata,
Y. Hayakawa,
H. Kinoshita,
W. Nakata,
K. Sakitani,
R. Takahashi,
M. Akanuma,
H. Kamata,
S. Maeda		 Oncogene. 2012 May 21.[Epub ahead of print]　
PubMed
Non-bismuth quadruple therapy for first-line Helicobacter pylori eradication: A randomized study in Japan. A. Yanai,
K. Sakamoto,
M. Akanuma,
K. Ogura,
S. Maeda		 World J Gastrointest Pharmacol Ther 3:1－6, 2012
PubMed
Efficacy and safety of exenatide once-weekly vs exenatide twice-daily in Asian patients with type 2 diabetes mellitus. （共同研究）
L. Ji,
Y. Onishi,
CW. Ahn,
P. Agarwal,
C-W. Chou,
H. Haber,
K. Guerrettaz,
MK. Boardman		 J Diabetes Invest Article first published online:14 SEP 2012
PubMed
Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes. （共同研究）
M. Iwashita,
H. Sakoda,
A. Kushiyama,
M. Fujishiro,
H. Ohno,
Y. Nakatsu,
T. Fukushima,
S. Kumamoto,
Y. Tsuchiya,
T. Kikuchi,
H. Kurihara,
H. Akazawa,
I. Komuro,
H. Kamata,
F. Nishimura,
T. Asano		 Am J Physiol Endocrinol Metab. 302:E286－296, 2012
PubMed
Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications. （共同研究）
H. Nakarai,
A. Yamashita,
S. Nagayasu,
M. Iwashita,
S. Kumamoto,
H. Ohyama,
M. Hata,
Y. Soga,
A. Kushiyama,
T. Asano,
Y. Abiko,
F. Nishimura		 Innate Immun. 18:164－170, 2012.
PubMed
Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages. （共同研究）
S. Kumamoto,
A. Kushiyama,
Y. Nakatsu,
H. Sakoda,
M. Fujishiro,
M. Iwashita,
H. Ohno,
J. Zhang,
Y. Guo,
H. Aburatani,
H. Kamata,
F. Nishimura,
T. Asano		 Obes Res Clin Pract. 6: e288-e297, 2012
PubMed
Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model. （共同研究）
Y. Nakatsu,
Y. Otani,
H. Sakoda,
J. Zhang,
Y. Guo,
H. Okubo,
A. Kushiyama,
M. Fujishiro,
T. Kikuch,
T. Fukushima,
H. Ohno,
Y. Tsuchiya,
H. Kamata,
A. Nagamachi,
T. Inaba,
F. Nishimura,
H. Katagiri,
S. Takahashi,
H. Kurihara,
T. Uchida,
T. Asano		 J Biol Chem. 287:44526－44535, 2012
PubMed
Risk of Cardiovascular Diseases Is Increased Even with Mild Diabetic Retinopathy: The Japan Diabetes Complications Study. （共同研究）
R. Kawasaki,
S. Tanaka,
S. Tanaka,
S. Abe,
H. Sone,
K. Yokote,
S. Ishibashi,
S. Katayama,
Y. Ohashi,
Y. Akanuma,
N. Yamada,
H. Yamashita; for the Japan Diabetes Complications Study Group		 Ophthalmology,
published online 20 November 2012. Corrected Proof 2012
PubMed
Sitafloxacin resistance in Helicobacter pylori isolates and sitafloxacin-based triple therapy as a third-line regimen in Japan. （共同研究）
Y. Hirata,
T. Ohmae,
A. Yanai,
K. Sakitani,
Y. Hayakawa,
S. Yoshida,
T. Sugimoto,
Y. Mitsuno,
M. Akanuma,
Y. Yamaji,
K. Ogura,
S. Maeda,
K. Koike		 Int J Antimicrob Agents 39: 352－355, 2012
PubMed
Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation. K. Sakitani,
Y. Hirata,
Y. Hayakawa,
T. Serizawa,
W. Nakata,
R. Takahashi,
H. Kinoshita,
K. Sakamoto,
H. Nakagawa,
M. Akanuma,
H. Yoshida,
S. Maeda,
K. Koike		 Infect Immun 80: 3795－3803, 2012
PubMed
Risk factors and early signs of pancreatic cancer in diabetes: screening strategy based on diabetes onset age. （共同研究）
S. Mizuno,
Y. Nakai,
H. Isayama,
A. Yanai,
N. Takahara,
K. Miyabayashi,
K. Yamamoto,
K. Kawakubo,
D. Mohri,
H. Kogure,
T. Sasaki,
N. Yamamoto,
N. Sasahira,
K. Hirano,
T. Tsujino,
H. Ijichi,
K. Tateishi,
M. Akanuma,
M. Tada,
K. Koike		 J Gastroenterol. Epub 2012 Jun 28
PubMed
Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer. （共同研究）
R. Takahashi,
Y. Hirata,
K. Sakitani,
W. Nakata,
H. Kinoshita,
Y. Hayakawa,
H. Nakagawa,
K. Sakamoto,
Y. Hikiba,
H. Ijichi,
HL. Moses,
S. Maeda,
K. Koike		 Cancer Sci. 2012 Dec 12.[Epub ahead of print]
PubMed
論文名 著者名 発表誌名
Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development. A. Kushiyama,
H. Okubo,
H. Sakoda,
T. Kikuchi,
M. Fujishiro,
H. Sato,
S. Kushiyama,
M. Iwashita,
F. Nishimura,
T. Fukushima,
Y. Nakatsu,
H. Kamata,
S. Kawazu,
Y. Higashi,
H. Kurihara,
T. Asano 		Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):291－298. Epub 2011 Nov 17.
PubMed
LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8 T. Kikuchi,
J. Zhang,
H. Sakoda,
Y. Koketsu,
M. Fujishiro,
A. Kushiyama,
Y. Nakatsu,
H. Kamata,
K. Inoki,
S. Takahashi,
H. Kurihara,
K. Hideki,
Y. Oka,
T. Asano		 Obesity Research & Clinical Practice,
In Press,
Corrected Proof,
Available online 26 October 2011
PubMed
Risk of macrovascular disease stratified by stage of chronic kidney disease in type 2 diabetic patients: critical level of the estimated glomerular filtration rate and the significance of hyperuricemia. K. Tanaka,
S. Hara,
A. Kushiyama,
Y. Ubara,
Y. Yoshida,
S. Mizuiri,
A. Aikawa,
S. Kawazu		 Clin Exp Nephrol. 2011 Jun;15(3):391－397. Epub 2011 Feb 18.
PubMed
Atrio-His (James) accessory pathway and infiltration of gd T-cells in the heart with MELAS. G. Matsuzaki,
A. Kushiyama,
K. Uto,
M. Shoda,
Y. Seko		 BMJ Case Reports 2011; doi:10.1136/bcr.09.2010.3359
PubMed
Colon cancer-derived factors activate NF-κB in myeloid cells via TLR2 to link inflammation and tumorigenesis. S. Maeda,
Y. Hikiba,
K. Sakamoto,
H. Nakagawa,
Y. Hirata,
Y. Hayakawa,
M. Akanuma		 Mol Med Report 4: 1083－1088, 2011
PubMed
Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase. H. Nakagawa,
Y. Hirata,
K. Takeda,
Y. Hayakawa,
T. Sato,
H. Kinoshita,
K. Sakamoto,
W. Nakata,
Y. Hikiba,
M. Omata,
H. Yoshida,
K. Koike,
H. Ichijo,
S. Maeda		 Hepatology 54:185－195, 2011
PubMed
75g経口ブドウ糖負荷2時間後尿中ミオイノシトールを指標とした耐糖能低下者の検出法の検討 河津捷二，
山縣文夫，
富永真琴，
足立雅樹，
池田 斉，
矢澤麻佐子，
土田温子，
松田 彰，
大村栄治，
松田昌文，
今井康雄，
桂 善也，
大嶋利枝，
鈴木幸子，
芳野 原，
岨 康二，
加計正文，
川上正舒		 糖尿病 54：27－33，2011
PubMed
1.日本人2型糖尿病患者における大血管合併症の疫学 曽根博仁，
山田信博，
赤沼安夫		 糖尿病 54：2－5，2011
PubMed
Constitutively active heat shock factor 1 enhances glucose-driven insulin secretion (共同研究)
T. Uchiyama,
S. Tomono,
T. Utsugi,
Y. Ohyama,
T. Nakamura,
H. Tomura,
S. Kawazu,
F. Okajima,
M. Kurabayashi		 Metabolism 60: 789－798, 2011
PubMed
Prevention of type 2 diabetes in a primary healthcare setting: Three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance (共同研究)
N. Sakane,
J. Sato,
K. Tsushita,
S. Tsujii,
K. Kotani,
K. Tsuzaki,
M. Tominaga,
S. Kawazu,
Y. Sato,
T. Usui,
I. Kamae,
T. Yoshida,
Y. Kiyohara,
S. Sato,
H. Kuzuya and Japan Diabetes Prevention Program (JDPP) Research Group the for		 BMC Public Health. 2011; 11: 40.
Published online 2011 January 17
PubMed
Low transition rate from normo- and low microalbuminuria to proteinuria in Japanese type 2 diabetic individuals: the Japan Diabetes Complications Study (JDCS). (共同研究)
S. Katayama,
T. Moriya,
S. Tanaka,
S. Tanaka,
Y. Yajima,
H. Sone,
S. Iimuro,
Y. Ohashi,
Y. Akanuma,
N. Yamada ; Japan Diabetes Complications Study Group.		 Diabetologia 54:1025－1031, 2011
PubMed
Incidence and progression of diabetic retinopathy in Japanese adults with type 2 diabetes: 8 year follow-up study of the Japan Diabetes Complications Study (JDCS). (共同研究)
R. Kawasaki,
S. Tanaka,
S.Tanaka,
T. Yamamoto,
H. Sone,
Y. Ohashi,
Y. Akanuma,
N. Yamada,
H. Yamashita and on behalf of the Japan Diabetes Complications Study Group		 Diabetologia 54:2288－2294, 2011
PubMed
Serum level of triglycerides is a potent risk factor comparable to LDL cholesterol for coronary heart disease in Japanese patients with type 2 diabetes: subanalysis of the Japan Diabetes Complications Study (JDCS). (共同研究)
H. Sone,
S. Tanaka,
S. Tanaka,
S. Iimuro,
K. Oida,
Y. Yamasaki,
S. Oikawa,
S. Ishibashi,
S. Katayama,
Y. Ohashi,
Y. Akanuma,
N. Yamada ; Japan Diabetes Complications Study Group.		 J Clin Endocrinol Metab. 96:3448－3456, 2011
PubMed
Insulin secretion and insulin sensitivity in Japanese patients with type 2 diabetes: a cross-sectional study comparing the homeostasis model assessment-2 (HOMA2) indexes and indexes derived from the oral glucose tolerance test (共同研究)
R. Yamamoto-Honda,
K. Osame,
H. Kitazato,
M. Shinkai-Goromaru,
A. Isogawa,
Y. Yoshida,
S. Kawazu,
Y. Akanuma,
M. Noda		 Diabetol Int 2:72－78, 2011
PubMed
Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer. (共同研究)
Y. Hayakawa,
Y. Hirata,
H. Nakagawa,
K. Sakamoto,
Y. Hikiba,
H. Kinoshita,
W. Nakata,
R. Takahashi,
K. Tateishi,
M. Tada,
M. Akanuma,
H. Yoshida,
K. Takeda,
H. Ichijo,
M. Omata,
S. Maeda,
K. Koike		 Proc Natl Acad Sci U S A 108:780－785, 2011
PubMed
MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma. (共同研究)
K. Kojima,
A. Takata,
C. Vadnais,
M. Otsuka,
T. Yoshikawa,
M. Akanuma,
Y. Kondo,
YJ. Kang,
T. Kishikawa,
N. Kato,
Z. Xie,
WJ. Zhang,
H. Yoshida,
M. Omata,
A. Nepveu,
K. Koike 		Nat Commun 2: 338, 2011
PubMed
Anti-tumor activity of the proteasome inhibitor bortezomib in gastric cancer. (共同研究)
W. Nakata,
Y. Hayakawa,
H. Nakagawa,
K. Sakamoto,
H. Kinoshita,
R. Takahashi,
Y. Hirata,
S. Maeda,
K. Koike		 Int J Oncol 39:1529－1536, 2011
PubMed
論文名 著者名 発表誌名
The effect of fasting plasma glucose variability on the risk of retinopathy in type 2 diabetic patients: Retrospective long-term follow-up T. Takao,
T. Ide,
H. Yanagisawa,
M. Kikuchi,
S. Kawazu,
Y. Matsuyama		 Diabetes Res Clin Pract 89: 296-302, 2010
PubMed
The effects of fasting plasma glucose variability and time-dependent glycemic control on the long-term risk of retinopathy in type 2 diabetic patients T. Takao,
T. Ide,
H. Yanagisawa,
M. Kikuchi,
S. Kawazu,
Y. Matsuyama		 Diabetes Res Clin Pract. 2011 Feb;91(2):e40-2. Epub 2010 Oct 29.
PubMed
Fasting tests of insulin secretion and sensitivity predict prediabetes in Japanese with normal glucose tolerance Y. Onishi,
T. Hayashi,
K.K. Sato,
T. Ogihara,
N. Kuzuya,
M. Anai,
K. Tsukuda,
E..J. Boyko,
W.Y. Fujimoto,
M. Kikuchi		 Journal of Diabetes Investigation Vol 1,
Issue 5,
191-195, 2010
PubMed
Ventricular tachyarrhythmia-related basal cardiomyopathy in rabbits with vagal stimulation—–A novel experimental model for inverted Takotsubo-like cardiomyopathy T. Takato,
T. Ashida,
Y. Seko,
J. Fujii,
S. Kawai		 Journal of Cardiology 56:85-90,2010
PubMed
Targeting NF-kappaB for colorectal cancer. K. Sakamoto,
S. Maeda		 Expert Opin Ther Targets. 14 :593-601, 2010
PubMed
Inhibitor of kappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression. K. Sakamoto,
Y. Hikiba,
H. Nakagawa,
Y. Hayakawa,
A. Yanai,
M. Akanuma,
K. Ogura,
Y. Hirata,
KH. Kaestner,
M. Omata,
S. Maeda		 Gastroenterology. 139 :226-38, 2010
PubMed
埼玉県における糖尿病患者の足外観異常および糖尿病性神経障害の実態調査に対する考察－足チェックシートを用いた検討 埼玉糖尿病対策推進会議（河津捷二） 日本医師会雑誌138：2323-2329, 2010
企業健診における尿中ミオイノシトール測定による耐糖能異常の検出 河津捷二,
山縣文夫,
坪井五三美,
富永真琴,
則武昌之		 日本人間ドック学会誌25:550-555, 2010
食事負荷試験における尿中ミオイノシトールと耐糖能の関係（その２） 山縣文夫,
金内則子,
高築勝義,
土田温子,
矢澤麻佐子,
今井康雄,
河津捷二		 日本人間ドック学会誌25:681-687, 2010
2型糖尿病患者におけるニ相性インスリン　アスパルト70(BIAsp 70)１日３回投与と二相性インスリン　アスパルト30(BIAsp30)１日２回投与時の24時間インスリン　プロファイルー健康成人の生理的インスリンプロファイルとの比較ー 佃　克則，
吉田洋子，
泉澤恭子，
入江　伸，
江藤　隆，
佐々木富雄，
菊池方利		 糖尿病53：237-246, 2010
PubMed
2型糖尿病の骨折に対する骨質治療による介入研究 櫛山暁史，
田原たづ，
吉田洋子，
岡安みね子，
黒田龍彦，
斎藤 充，
熊田真幸，
板橋 明，
菊池方利，
河津捷二		 Osteoporosis Japan 18:678-682, 2010
糖尿病患者に対するインスリン抵抗性介入がもたらす動脈硬化症への影響のバイオアッセイ 櫛山暁史,
浅野知一郎,
佃 克則,
大西由希子		 第41回医学研究助成研究報告集 平成20年pp11-13
2型糖尿病患者におけるビルダグリプチンの臨床評価 菊池方利,
岩本安彦,
稲垣暢也,
吉岡卓也,
三森信幸,
海老名寛子		 新薬と臨床 59：121-136, 2010
2型糖尿病患者におけるビルダグリプチンの長期投与での臨床評価 菊池方利,
宇都宮一典,
守屋達美,
寺尾新司,
北脇哲二,
三森信幸,
海老名寛子		 新薬と臨床 59：137-154, 2010
スピロノラクトンによる疼痛を伴った女性化乳房がエプレレノンに変更後改善した原発性アルドステロン症の1例 高遠哲也、芦田映直、松崎　弦、世古義規 診断と治療98:859-861,2010
Long-term lifestyle intervention lowers the incidence of stroke in Japanese patients with type type 2 diabetes:a nationwide multicentre randomised controlled trial（the Japan Diabetes Complication Study） (共同研究)
H.Sone,
S.Tanaka,
S.Iimuro,
S.Tanaka,
K.Oida,
Y.Yamasaki,
S.Oikawa,
S.Ishibashi,
S.Katayama,
H.Yamashita,
H.Ito,
Y.Yoshimura,
Y.Ohashi,
Y.Akanuma,
N.Yamada		 Diabetologia 53：419-428, 2010
PubMed
Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses. (共同研究)
Y. Hayakawa,
Y. Hirata,
H. Nakagawa,
K. Sakamoto,
Y. Hikiba,
M. Otsuka,
H. Ijichi,
T. Ikenoue,
K. Tateishi,
M. Akanuma,
K. Ogura,
H. Yoshida,
H. Ichijo,
M. Omata,
S. Maeda		 Gastroenterology. 138 :1055-67, 2010
PubMed
Efficacy and tolerability of vildagliptin as an add-on to glimepiride in Japanese patients with Type 2 diabetes mellitus. M. Kikuchi,
M. Haneda,
D. Koya,
K. Tobe,
Y. Onishi,
A. Couturier,
N. Mimori,
Y. Inaba,
M. Goodman		 Diabetes Res Clin Pract. 89: 216─223, 2010
PubMed
論文名 著者名 発表誌名
Evaluation of the 24─hour profiles of physiological insulin, glucose, and C-peptide in healthy Japanese volunteers K. Tsukuda,
M. Kikuchi,
S. Irie,
T. Eto,
A.Yamada,
K. Matsuguma,
T. Sasaki,
Y. Katayama		 Diabetes Technol Ther 11: 499-508, 2009

PubMed
Waist circumference as a cardiovascular and metabolic risk in Japanese patients with type 2 diabetes H. Sone,
S. Tanaka,
S. Iimuro,
K. Oida,
Y. Yamasaki,
S. Ishibashi,
S. Oikawa,
S. Katayama,
H. Ito,
Y. Ohashi,Y. Akanuma,
N. Yamada		 Obesity 17: 585-592, 2009

PubMed
Components of metabolic syndrome and their combinations as predictors of cardiovascular disease in Japanese patients with type 2 diabetes. Implications for improved definition. Analysis from Japan Diabetes Complications Study（JDCS） H. Sone,
S. Tanaka,
S. Iimuro,
K. Oida,
Y. Yamasaki,
S. Oikawa,
S. Ishibashi,
S. Katayama,
H. Ito,
Y. Ohashi,
Y. Akanuma,
N. Yamada		 J Atheroscler Thromb 16: 380-387, 2009

PubMed
Vildagliptin dose-dependently improves glycemic control in Japanese patients with type 2 diabetes mellitus M. Kikuchi,
N. Abe,
M. Kato,
S. Terao,
N. Mimori,
H. Tachibana		 Diabetes Res Clin Pract 83: 233-240, 2009

PubMed
Addition of mitiglinide to pioglitazone monotherapy improves overall glycemic control in Japanese patients with type 2 diabetes: A randomized double blind trial K. Kaku,
S. Tanaka,
H. Origasa,
M. Kikuchi,
Y. Akanuma		 Endocr J 56: 657-664, 2009

PubMed
Effect of mitiglinide on glycemic control over 52 weeks in Japanese type 2 diabetic patients insufficiently controlled with pioglitazone monotherapy K. Kaku,
S. Tanaka,
H. Origasa,
M. Kikuchi,
Y. Akanuma		 Endocr J 56: 739-746, 2009

PubMed
Left bundle branch block with intermittent QRS axis switching. Observations of a hypertensive patient for 18 years T. Takato,
N. Yamada,
J. Fujii,
S. Mashima,
T. Ashida		 Int Heart J 50: 677-684, 2009

PubMed
Constitutive NF-кB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth K. Sakamoto,
S. Maeda,
Y. Hikiba,
H. Nakagawa,
Y. Hayakawa,
W. Shibata,
A. Yanai,
K. Ogura,
M. Omata		 Clin Cancer Res 15: 2248-2258, 2009

PubMed
Ikappa B kinaseb/nuclear factor-lB activation controls the development of liver metastasis by way of interleukin─6 expression S. Maeda,
Y. Hikiba,
K. Sakamoto,
H. Nakagawa,
Y. Hirata,
Y. Hayakawa,
A. Yanai,
K. Ogura,
M. Karin,
M. Omata		 Hepatology 50: 1851-1860, 2009

PubMed
Effectiveness of IlB kinase inhibitors in murine colitis-associated tumorigenesis Y. Hayakawa,
S. Maeda,
H. Nakagawa,
Y. Hikiba,
W. Shibata,
K. Sakamoto,
A. Yanai,
Y. Hirata,
K. Ogura,
S. Muto,
A. Itai,
M. Omata		 J Gastroenterol 44: 935-943, 2009

PubMed
インタクトプロインスリン／インスリンモル比の特徴と臨床的意義（その1）─基準値の設定と耐糖能障害における膵β細胞機能との関係─ 河津捷二，
矢澤麻佐子，
今井康雄，
堀江　均，
久野義和，
小山雄平，
石田　均，
小澤幸彦，
鈴木　清，
岩本安彦，
佐倉　宏，
金澤康徳，
河盛隆造，
内野　泰，
小林哲郎，
会田薫，
伴野祥一，
長坂昌一郎，
松葉育郎，
丸山太郎，
税所芳史，
葛谷　健		 糖尿病52：537-545, 2009
インタクトプロインスリン／インスリンモル比の特徴と臨床的意義（その2）─2型糖尿病患者における各種パラメータとの相関解析および経口血糖降下薬の影響─ 河津捷二，
矢澤麻佐子，
今井康雄，
堀江　均，
久野義和，
小山雄平，
石田　均，
小澤幸彦，
鈴木　清，
岩本安彦，
佐倉　宏，
金澤康徳，
河盛隆造，
内野　泰，
小林哲郎，
会田薫，
伴野祥一，
長坂昌一郎，
松葉育郎，
丸山太郎，
税所芳史，
葛谷　健		 糖尿病52：547-554, 2009
糖尿病患者における網膜症発症への血糖変動と年齢の影響─30年以上の長期通院患者での研究─ 高尾淑子，
岡安みね子，
柳澤裕之，
菊池方利		 日老医誌46：528-536, 2009
PubMed
ピオグリタゾン塩酸塩単独療法で血糖管理不十分な2型糖尿病患者を対象としたナテグリニドとピオグリタゾン塩酸塩併用の臨床効果─第・／・相二重盲検群間比較試験─ 菊池方利，
浜田知久馬		 臨床医薬25：35-56, 2009
ピオグリタゾン塩酸塩単独療法で血糖管理不十分な2型糖尿病患者を対象としたナテグリニドとピオグリタゾン塩酸塩の長期併用投与による有用性の検討（第・／・相二重盲検群間比較試験からの継続投与）─多施設共同非盲検試験─ 菊池方利 臨床医薬25：57-75, 2009
論文名 著者名 発表誌名
Distribution of blood glucose and the correlation between blood glucose and hemoglobin A1c levels in diabetic outpatients R. Yamamoto-Honda,
H. Kitazato,
S. Hashimoto,
Y. Takahashi,
Y. Yoshida,
C. Hasegawa,
Y. Akanuma,
M. Noda		 Endocr J 55 : 913－923, 2008

PubMed
Activation of IkappaB kinase and NF－kappaB is essential for Helicobacter pylori-induced chronic gastritis in Mongolian gerbils A. Yanai,
S. Maeda,
W. Shibata,
Y. Hikiba,
K. Sakamoto,
H. Nakagawa,
T. Ohmae,
Y. Hirata,
K. Ogura,
S. Muto,
A. Itai,
M. Omata		 Infect Immun 76 : 781－787, 2008

PubMed
Effects of aging and sex on progression of carotid intima-media thickness : A retrospective 6－year follow-up study T. Takato,
N. Yamada,
T. Ashida		 Geriatr Gerontol Int 8 : 172－179, 2008

PubMed
Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells M. Egawa,
H. Kamata,
A. Kushiyama,
H. Sakoda,
M. Fujishiro,
N. Horike,
M. Yoneda,
Y. Nakatsu,
G. Ying,
Z. Jun,
Y. Tsuchiya,
K.Takata,
H. Kurihara,
T. Asano		 Placenta 29 : 1003－1008, 2008

PubMed
AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver N. Horike,
H. Sakoda,
A. Kushiyama,
H. Ono,
M. Fujishiro,
H. Kamata,
K. Nishiyama,Y. Uchijima,
Y. Kurihara,
H. Kurihara,
T. Asano		 J Biol Chem 283 : 33902－33910, 2008

PubMed
Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice Y. Koketsu,
H. Sakoda,
M. Fujishiro,
A. Kushiyama,
Y. Fukushima,
H. Ono,
M. Anai,
T. Kikuchi,
T. Fukuda,
H. Kamata,
N. Horike,
Y. Uchijima,
H. Kurihara,
T. Asano		 Am J Physiol Endocrinol Metab 294 : E719－725, 2008

PubMed
Mortality from gastric cancer in patients followed with upper gastrointestinal endoscopy M. Ogura,
Y. Hikiba,
S. Maeda,
M. Matsumura,
K. Okano,
R. Sassa,
H. Yoshida,
T. Kawabe,
M. Omata		 Scand J Gastroenterol 43 : 574－580, 2008

PubMed
c－Jun NH2－terminal kinase 1 is a critical regulator for the development of gastric cancer in mice W. Shibata,
S. Maeda,
Y. Hikiba,
A. Yanai,
K. Sakamoto,
H. Nakagawa,
K. Ogura,
M. Karin,
M. Omata		 Cancer Res 68 : 5031－5039, 2008

PubMed
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation H. Nakagawa,
S. Maeda,
Y. Hikiba,
T. Ohmae,
W. Shibata,
A. Yanai,
K. Sakamoto,
K. Ogura,
T. Noguchi,
M. Karin,
H. Ichijo,
M. Omata		 Gastroenterology 135 : 1311－1321, 2008

PubMed
頸動脈内膜中膜複合体厚（IMT）とPWV，ABI，AIとの関連についての検討 高遠哲也，
八尾貴子，
世古義規，
芦田映直		 血圧　15 : 900－901，2008
高血圧，糖尿病，高脂血症で外来通院中に非動脈炎性前部虚血性視神経症を発症し内頸動脈高度狭窄の関与が考えられた1例 高遠哲也，
芦田映直，
山田奈美恵，
穴井元暢，
堀　貞夫，
岡田芳和		 日老医誌　45 : 100－106，2008

PubMed
論文名 著者名 発表誌名
Use of Insulin Glargine in Japanese Patients with type 1 Diabetes R. Yamamoto-Honda,
Y. Takahashi,
Y. Yoshida,
Y. Hara,
A. Kawai,
H. Kitazato,
T. Tanaka,
H. Kajio,
M. Kikuchi,
Y. Akanuma,
M. Noda		 Intern Med 46 : 937－943, 2007

PubMed
Effects of Short-Term Hypocaloric Diet on Sympatho-Vagal Interaction Assessed by Spectral Analysis of Heart Rate and Blood Pressure Variability during Stress Tests in Obese Hypertensive Patients T. Ashida,
C. Ono,
T. Sugiyama		 Hypertens Res　30 : 1199－1203, 2007

PubMed
Essential roles of high－mobility group box 1 in the development of murine colitis and colitis－associated cancer S. Maeda,
Y. Hikiba,
W. Shibata,
T. Ohmae,
A. Yanai,
K,
Ogura,
S,
Yamada,
M. Omata		 Biochem Biophys Res Commun 360 : 394－400, 2007

PubMed
Gender disparity in liver cancer due to sex differences in MyD88-depen-dent IL-6 production. WE. Naugler,
T. Sakurai,
S,
Kim,
S. Maeda,
K. Kim,
AM. Elsharkawy,
M. Karin		 Science 317 : 121－124, 2007

PubMed
Clinical relevance of Helicobacter pylori sabA genotype in Japanese clinical isolates A. Yanai,
S. Maeda,
Y. Hikiba,
W. Shibata,
T. Ohmae,
Y. Hirata,
K. Ogura,
H. Yoshida,
M. Omata		 J Gastroenterol Hepatol　22 : 2228－2232, 2007

PubMed
Cutting Edge : The IκB Kinase（IKK）inhibitor, NEMO-Binding domain peptide, blocks inflammatory injury in murine colitis1 W. Shibata,
S. Maeda,
Y. Hikiba,
A. Yanai,
T. Ohmae,
K. Sakamoto,
H. Nakagawa,
K. Ogura,
M. Omata		 J Immunol 179 : 2681－2685, 2007

PubMed
頸動脈超音波検査時に偶然発見された内頸静脈血栓の1例 吉川美帆，
常田智子，
笹谷早苗，
福井美弥子，
山本美津代，
本田律子		 超音波検査技術　32 : 418－421，2007
論文名 著者名 発表誌名
Variation in parasystolic cycle length observations of a hypertensive patient for over six years C. Ono,
T. Ashida,
T. Sugiyama,
J.Fujii,
K. Takayanagi		 Int Heart J 47: 153-158, 2006

PubMed
Marked reversible ST-T abnormalities induced by cardiac compression from a retrosternal gastric tube used to reconstruct the esophagus after tumor resection. A case of a diabetic patient and mini-review of 7 reported patients T. Takato,
T. Ashida,
T. sugiyama,Y. Yoshida		 Int Heart J 47: 475-482, 2006

PubMed
Gastric cnacer among peptic ulcer patients: Retrospective, long-term follow-up M. Ogura,
Y. Yamaji,
Y. Hikiba,S. Maeda,
M. Matsumura,
K. Okano,R. Sassa,
H. Yoshida,
T. Kawabe,M. Omata		 Dig Liver Dis 38: 811-814, 2006

PubMed
CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model W. Shibata,
Y. Hirata,
S. Maeda,
K. Ogura,
T. Ohmae,
A. Yanai,
Y. Mitsuno,
Y. Yamaji,
M. Okamoto,
H. Yoshida,
T. Kawabe,
M. Omata		 J Pathol 210: 306-314, 2006

PubMed
論文名 著者名 発表誌名
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis M. Anai,
N. Shojima,
H. Katagiri,
T. Ogihara,
H. Sakoda,
Y. Onishi,
H. Ono,
M. Fujishiro,
Y. Fukushima,
N. Horike,
A. Viana,
M. Kikuchi,
N. Noguchi,
S. Takahashi,
K. Takata,
Y. Oka,
Y. Uchijima,
H. Kurihara,
T. Asano		 J Biol Chem 280: 18525-18535, 2005

PubMed
Fluvastatin ameliorates the hyperhomocysteinemia-induced endothelial dysfunction – The antioxidative properties of fluvastatin – H. Morita,
Y. Saito,
N. Ohashi,
M. Yoshikawa,
M. Katoh,
T. Ashida,
H.Kurihara,
T.Nakamura,
M. Kurabayashi,
R. Nagai		 Circ J　69: 475-480, 2005

PubMed
IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis S. Maeda,
H. Kamata,
JL. Luo,
H. Leffert,
M. Karin		 Cell 121: 977-990, 2005

PubMed
Nod2 mutation in Crohn’s disease potentiates NF-κB activity and IL-1β processing S. Maeda,
LC. Hsu,
H. Liu ,
LA. Bankston,
M. Iimura,
MF. Kagnoff,
L. Eckmann,
M. Karin		 Science 307: 734-738, 2005

PubMed
Functional consequences of mutations in a putative Akt phosphorylation motif of B-raf in human cancers T. Ikenoue,
F. Kanai,
Y. Hikiba,
Y. Tanaka,
J. Imamura,
M. Ohta,
A. Jazag,
B. Guleng,
Y. Asaoka,
K. Tateishi,
T. Kawakami,
M. Matsumura,
T. Kawabe,
M. Omata		 Mol Carcinog 43: 59-63, 2005

PubMed
Functional analysis of PIK3CA gene mutations in human colorectal cancer T. Ikenoue,
F. Kanai,
Y. Hikiba,
T. Obata,
Y. Tanaka,
J. Imamura,
M. Ohta,
A. Jazag,
B. Guleng,
K. Tateishi,
Y. Asaoka,
M. Matsumura,
T. Kawabe,
M. Omata		 Cancer Res 65: 4562-4567, 2005

PubMed
論文名 著者名 発表誌名
1,5-anhydroglucitol値と糖尿病網膜症の発症についての検討 星野和彦，
赤沼安夫		 糖尿病47: 845-850, 2004

PubMed
1型糖尿病発症後に大動脈炎症候群が併発し，糖尿病網膜症が興味深い経過を辿った1例 村岡都美江，
吉田洋子，
羽倉稜子，
赤沼安夫，
福田全克		 糖尿病47: 453-458, 2004

PubMed
Characterization of the portal signal during 24-h glucose delivery in unrestrained,
conscious rats		 N. Ogihara,
W. Kawamura,
K. Kasuga,
Y. Hayashi,
H. Arakawa,
M. Kikuchi		 Am J Physiol Endocrinol Metab 286: E932-E940, 2004

PubMed
Mitral valve hemorrhage and mitral annulus shrinkage in rabbits with transient ventricular bigeminies induced by vagal stimulation T. Ashida,
C. Ono,
T. Sugiyama,
J Fujii		 J Heart Valve Dis 13: 779-783, 2004

PubMed
高血圧，陳旧性心筋梗塞，高脂血症で28年間経過観察中に腹部大動脈瘤破裂術後11年で胸部大動脈瘤破裂にて死亡した86歳男性の1剖検例 小野周子，
芦田映直，
杉山卓郎，
藤井　潤，
本間　栄，
谷本昭英		 日老医誌 41: 670-674, 2004

PubMed
Rapid detection of mutations in the BRAF gene using real-time polymerase chain reaction and melting curve analysis T. Ikenoue,
Y. Hikiba,
F. Kanai,
H. Ijichi,
G. Togo,
M. Ohta,
H. Watabe,
Y. Yamaji,
M. Okamoto,
J. Aragaki,
M. Matsumuma,
T. Kawabe,
M. Omata		 Cancer Genet Cytogenet 149: 68-71, 2004

PubMed
Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein / extracellular signal-regulated kinase kinase / extracellular signal-regulated kinase and nuclear factor κB pathway and cellular transformation T. Ikenoue,
Y. Hikiba,
F. Kanai,
J. Aragaki,
Y. Tanaka,
J. Imamura,
T. Imamura,
M. Ohta,
H. Ijichi,
K. Tateishi,
T. Kawakami,
M. Matsumura,
T. Kawabe,
M. Omata		 Cancer Res 64: 3428-3435, 2004

PubMed
論文名 著者名 発表誌名
糖尿病内科外来の初診時における糖尿病網膜症の頻度－HbA1cを指標とした糖尿病の重症度との検討－ 吉田洋子，
羽倉稜子，
原　陽子，
関　詩子，
西澤由美子，
田中うた代，
後藤直子，
福田全克		 眼紀 54: 334-338, 2003
Differing roles of Akt and serum-and glucocorticoid-regulated kinase in glucose metabolism,DNA synthesis,
and oncogenic activity		 H. Sakoda,
Y. Gotoh,
H. Katagiri,
M. Kurokawa,
H. Ono,
Y. Onishi,
M. Anai,
T. Ogihara,
M. Fujishiro,
Y. Fukushima,
M. Abe,
N. Shojima,
M. Kikuchi		 J Biol Chem 278: 25802-25807, 2003

PubMed
Ethanol feeding induces insulin resistance with enhaced PI 3-kinase activation Y. Onishi,
M. Honda,
T. Ogihara,
H. Sakoda,
M. Anai,
M. Fujishiro,
H. Ono,
N. Shojima,
Y. Fukushima,
K. Inukai,
H. Katagiri,
M. Kikuchi,
Y. Oka,
T. Asano		 Biochem Biophys Res Commun 303: 788-794, 2003

PubMed
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement H. Ono,
H. Shimano,
H. Katagiri,
N. Yahagi,
H. Sakoda,
Y. Onishi,
M. Anai,
T. Ogihara,
M. Fujishiro,
A.Y.I. Viana,
Y. Fukushima,
M. Abe,
N. Shojima,
M. Kikuchi,
N. Yamada,
Y. Oka,
T. Asano		 Diabetes 52: 2905-2913, 2003

PubMed
Characterization of the portal signal in a nonsteady hyperglycemic state in conscious dogs N. Ogihara,
S. Ebihara,
W. Kawamura,
M. Okamoto,
T. Sakai,
K. Takiguchi,
T. Morita,
R. Uchida,
Y. Matsuyama,
Y. Hayashi,
Y. Arakawa,
M. Kikuchi		 Am J Physiol 284: E148-E155, 2003

PubMed
Mitral complex lesions following vagal stimulation in rabbits: Relationship between the direction of mitral regurgitation jet and the site of mitral complex lesions T. Ashida,
S. Okuno,
A. Ebihara,
T. Sugiyama,
J. Fujii		 J Heart Valve Dis 12: 308-312, 2003

PubMed
Diabetes influences the cardiac symptoms related to atrial fibrillation K. Sugishita,
E. Shiono,
T. Sugiyama,
T. Ashida		 Circ J 67: 835-838, 2003

PubMed
ニフェジピンCoat Core錠の夕食後投与や眠前投与が早期高血圧の改善に有効であった３症例 杉山卓郎 臨牀と研究 80: 1376-1381, 2003
心筋梗塞後10年目で左心室瘤を形成，
12年目で心室瘤内血栓様エコーを呈し，
13年目に脳梗塞を合併した高齢者の1例		 塩野悦子，
芦田映直，
杉下和郎，
杉山卓郎，
藤井　潤		 日老医誌 40: 172-175, 2003

PubMed
Left ventricular regional variations in myosin isoform shift in Dahl salt-sensitive hypertensive rats S. Sakurai,
T. Ashida,
K. Ieki,
N. Takahashi,
J. Fujii		 Hypertens Res 26: 251-255, 2003

PubMed
Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors T. Ikenoue,
Y. Hikiba,
F. Kanai,
Y. Tanaka,
J. Imamura,
T. Imamura,
M. Ohta,
H. Ijichi,
K. Tateishi,
T. Kawakami,
J. Aragaki,
M. Matsumura,
T. Kawabe,
M. Omata		 Cancer Research 63: 8132-8137, 2003

PubMed
Synergistic activation of the serum response element-dependent pathway by hepatitis B virus X protein and large-isoform hepatitis delta antigen T. Goto,
N. Kato,
H. Yoshida,
M. Otsuka,
M. Moriyama,
Y. Shiratori,
K. Koike,
M. Matsumura,
M. Omata		 JID 187-820-828, 2003

PubMed
論文名 著者名 発表誌名
Switch to anaerobic glucose metabolism with NADH accumulation in the β-cell model of mitochondrial diabetes: Characteristics of βHC9 cells deficient in mitochondrial DNA transcription M. Noda,
S. Yamashita,
N. Takahashi,
K. Eto,
L.Shen,
K. Izumi,
S. Daniel,
Y. Tsubamoto,
T. Nemoto,
M. Iino,
H. Kasai,
G.W.G. Sharp,
T. Kadowaki		 J Biol Chem 277: 41817-41826, 2002

PubMed
糖尿病における血管合併症の発症予防と進展抑制に関する研究 野田光彦 平成13年度厚生科学研究費補助金健康科学総合研究事業研究報告書: 68, 2002
糖尿病とその合併症の治療・予防についての最適ストラテジーの探索とそのデータベース化 野田光彦 平成13年度厚生科学研究補助金21世紀型医療開拓推進研究事業研究報告書: 1-5, 2002
科学的根拠（evidence）に基づく糖尿病診療ガイドラインの策定に関する研究 野田光彦 平成12年度厚生科学研究補助金医療技術評価総合研究事業研究報告書, 2002
厚生労働省多目的コホート班との共同による糖尿病実態及び発症要因の研究 野田光彦 平成13年度厚生科学研究費補助金21世紀型医療開拓推進研究事業研究報告書: 7-18, 2002
Screening and follow-up of diabetic retinopathy using a new mosaic 9-field fundus photography system T. Shiba,
T. Yamamoto,
U. Seki,
N. Utsugi,
K. Fujita,
Y. Sato,
H. Terada,
H. Sekihara,
R. Hagura		 Diabetes Res Clin Pract 55: 49-59, 2002

PubMed
Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes H. Sakoda,
T. Ogihara,
M. Anai,
M. Fujishiro,
H. Ono,
Y. Onishi,
H. Katagiri,
M. Abe,
Y. Fukushima,
N. Shojima,
K. Inukai,
M. Kikuchi,
Y. Oka,
T. Asano		 Am J Physiol Endocrinol Metab 282: E1239-E1244, 2002

PubMed
Comparison of insulinotrophic actions of nateglinide with glibenclamide dissociated from absorption in conscious dogs M. Okamoto,
N. Ogihara,
W. Kawamura,
S. Ebihara,
K. Takiguchi,
T. Morita,
R. Uchida,
J. Yamaguchi,
T. Sakai,
Y. Okuda,
Y. Hayashi,
Y. Arakawa,
M. Kikuchi		 Metabolism 51: 575-581, 2002

PubMed
眼球雑音を聴取し血管造影により頭蓋内内頸動脈狭窄を認めた高齢者高血圧の1例 海老原文，
芦田映直，
杉山卓郎，
奥野　茂，
藤井　潤，
米満　勤		 日老医誌 39: 94-96, 2002

PubMed
27年間経過を観察し進行性狭窄症と心不全を呈して死亡した高齢者先天性大動脈二尖弁の１剖検例 横山　聡，
芦田映直，
杉山卓郎，
海老原文，
藤井　潤，
千田宏司，
江崎行芳，
大川真一郎		 日老医誌 39: 444-447, 2002

PubMed
論文名 著者名 発表誌名
糖尿病における血管合併症の発症予防と進展抑制に関する研究 赤沼安夫 平成12年度厚生科学研究費補助金健康科学総合研究事業研究報告書 : 59-97, 2001
厚生省多目的コホート班との共同による糖尿病実態及び発症要因の研究 野田光彦 平成13年厚生科学研究費補助金21世紀型医療開拓推進研究事業研究報告書 : 7-18, 2002
Risk factors for the development of diabetic retinopathy in Japanese type 2 diabetic patients Y. Yoshida,
R. Hagura,
Y. Hara,
G. Sugasawa,
Y. Akanuma		 Diab Res Clin Pract 51: 195-203, 2001

PubMed
Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats T. Ogihara,
T. Asano,
K. Ando,
Y. Chiba,
N. Sekine,
H. Sakoda,
M. Anai,
Y. Onishi,
M. Fujishiro,
H. Ono,
N. Shojima,
K. Inukai,
Y. Fukushima,
M. Kikuchi,
T. Fujita		 Diabetes 50: 573-583, 2001

PubMed
Unique phosphorylation mechanism of Gab1 using PI3-kinase as an adaptor protein Y. Onishi-Haraikawa,
M. Funaki,
N. Gotoh,
M. Shibuya,
K. Inukai,
H. Katagiri,
Y. Fukushima,
M. Anai,
T. Ogihara,
H. Sakoda,
H. Ono,
M. Kikuchi,
Y. Oka,
T. Asano		 BBRC 288: 476-482, 2001

PubMed
Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (Phosphatase and tensin homolog delated on chromosome10) in 3T3-L1 adipocytes H. Ono,
H. Katagiri,
M. Funaki,
M. Anai,
K. Inukai,
Y. Fukushima H. Sakoda,
T. Ogihara,
Y. Onishi,
M. Fujishiro,
M. Kikuchi,
Y Oka,
T. Asano		 Molecular Endocrinology 15: 1411-1422, 2001

PubMed
Relationship between hepatic glucose uptake and load in non-steady state physiological glucose excursions in dogs J. Yamaguchi,
N. Ogihara,
M. Imatake,
S. Ebihara,
W. Kawamura,
T. Morita,
R. Uchida,
Y. Hayashi,
Y. Arakawa,
M. Kikuchi		 Nihon Univ J Med 43: 97-110, 2001
Profiles of patients who control the doses of their antihypertensive drugs by self-monitoring of home blood pressure T. Ashida,
S. Yokoyama,
A. Ebihara,
T. Sugiyama,
J. Fujii		 Hypertens Res 24: 203-207, 2001

PubMed
長期間社会的活動を維持しえた心不全85歳男性剖検例にみられた多因子性心疾患による著明な心肥大 奥野　茂，
芦田映直，
海老原文，
杉山卓郎，
藤井　潤，
千田宏司，
江崎行芳，
大川真一郎		 日老医誌 38: 819-821, 2001

PubMed
Evaluation of selected polymorphisms of the Mendelian hypertensive disease genes in the Japanese population T. Sugiyama,
N. Kato,
Y. Ishinaga,
Y. Yamori,
Y. Yazaki		 Hypertens Res 24: 515-521, 2001

PubMed
糖尿病のよりよい食事療法のためのごはん食の研究 杉山卓郎，
児島そのえ		 ごはん食基礎データ蓄積事業　報告書（平成12年度　委託研究事業）財団法人　全国米穀協会 : 118-128, 2001
Medication management skill and regimen compliance are deteriorated in the elderly even without obvious dementia H. Yamada,
T. Sugiyama,
T. Ashida,
H. Ohwaki,
J. Fujii		 YAKUGAKU ZASSHI 212: 187-190, 2001

PubMed
Rapid detection of mutations in the 23S rRNA gene of Helicobacter pylori that confers resistance to clarithromycin treatment to the bacterium M. Matsumura,
Y. Hikiba,
K. Ogura,
G Togo,
I Tsukuda,
K. Ushikawa,
Y. Shiratori,
M. Omata		 J Clin Microbiol 39: 691-695, 2001

PubMed
Simple quantitative assay of alphafetoprotein mRNA in liver tissue using the real-time detection polymerase chain reaction assay – its application for clinical use M. Matsumura,
M. Ijichi,
Y. Shiratori,
G. Togo,
Y. Hikiba,
K. Inoue,
M. Kohara,
M. Omata		 Hepatol Res 20: 84-96, 2001

PubMed
Frameshift mutations at mononucleotide repeats in RAD50 recombinational DNA repair gene in colorectal cancers with microsatellite instability T. Ikenoue,
G. Togo,
K. Nagai,
H.,
Ijichi,
J. Kato,
Y. Yamaji,
M. Okamoto,
N. Kato,
T. Kawabe,
A. Tanaka,
M. Matsumura,
Y. Shiratori,
M. Omata		 Jpn J Cancer Res 92: 587-591, 2001

PubMed
Relationship between grade of microsatellite instalibity and target genes of mismatch repair pathways in sporadic colorectal carcinoma G. Togo,
Y. Shiratori,
M. Okamoto,
Y. Yamaji,
M. Matsumura,
T. Sano,
T. Motojima,
M. Omata		 Dig Dis Sci 46: 1615-1622, 2001

PubMed
慢性疾患専門外来における予約診療の現状－朝日生命成人病研究所における最近9年間の調査－ 石井治子，
西田マリ子，
長谷川静美，
生松めぐみ		 病院管理 311: 41-47, 2001
論文名 著者名 発表誌名
糖尿病における血管合併症の発症予防と進展抑制に関する研究 赤沼安夫 平成11年度厚生科学研究費補助金健康科学総合研究事業研究報告書 : 65-102, 2000
Diabetes mellitus and life-style – for the primary prevention of diabetes mellitus: the role of diet R. Hagura Br J Nutr 84 (suppl 2): S191-S194, 2000

PubMed
Overexpression of the glycogen targeting (GM) subunit of protein phosphatase-1 R. Yamamoto-Honda,
Z. Honda,
Y. Kaburagi,
K. Ueki,
S. Kimura,
Y. Akanuma,
T. Kadowaki		 Biochem Biophys Res Commun 275: 859-864, 2000

PubMed
p110β is up-regulated during differentiation of 3T3-L1 cells and contributes to the highly insulin-responsive glucose transport activity T. Asano,
A. Kanda,
H. Katagiri,
M. Nawano,
T. Ogihara,
K. Inukai,
M. Anai,
Y. Fukushima,
Y. Yazaki,
M. Kikuchi,
R. Hooshmand-Rad,
C. Heldin,
Y. Oka,
M. Funaki		 J Biol Chem 275: 17671-17676, 2000

PubMed
Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction H. Sakoda,
T. Ogihara,
M. Anai,
M. Funaki,
K. Inukai,
H. Katagiri,
Y. Fukushima,
Y. Onishi,
H. Ono,
M. Fujishiro,
M. Kikuchi,
Y. Oka,
T. Asano		 Diabetes 49: 1700-1708, 2000

PubMed
Escalating dose study of a novel non-SU agent, A-4166, in type 2 diabetes K. Takiguchi,
H. Ishihara,
Y. Ohashi,
K. Kosaka,
Y. Hayashi,
Y. Arakawa,
M. Kikuchi		 Nihon Univ J Med 42: 31-45, 2000
Transient mitral regurgitation following vagal stimulation-induced ventricular arrhythmia in rabbits: a color doppler echocardiographic study T. Ashida,
S. Okuno,
A. Ebihara,
T. Sugiyama,
J. Fujii		 J Heart Valve Dis 9: 269-272, 2000

PubMed
Relationship between home blook pressure measurement and medication compliance and name recognition of antihypertensive drugs T. Ashida,
T. Sugiyama,
S. Okuno,
A. Ebihara,
J. Fujii		 Hypertens Res 23: 21-24,

PubMed
Distinct incerase in hematocrit associated with paroxysm of atrial fibrillation S. Okuno,
T. Ashida,
A. Ebihara,
T. Sugiyama,
J. Fujii		 Jpn Heart J 41: 617-622, 2000

PubMed
Increases in intracellular calcium of arterial smooth muscle cells in transgenic mice overexpressing Na+/H+ exchanger J. Kiraku,
T. Sugiyama,
T. Ashida,
N,
Takahashi,
J. Fujii,
M. Kuro-o,
R. Nagai		 J Cardiovasc Pharmacol 35: 511-513, 2000

PubMed
28年にわたる長期観察中にPR時間延長とQRS幅正常化を認めたWPW症候群の１例 喜楽順一，
杉山卓郎，
芦田映直，
藤井　潤，
春見建一		 心臓 32: 645-650, 2000
Virulence factors of helicobacter pylori responsible for gastric disease in mongolian gerbil K. Ogura,
S. Maeda,
M. Nakao,
T. Watanabe,
M. Tada,
T. Kyutoku,
H. Yoshida,
Y. Shiratori,
M. Omata		 J Exp Med 192: 1601-1609, 2000

PubMed
Is fetal microchimerism involved in primary biliary cirrhosis ? A. Tanaka,
K. Lindor,
A. Ansari,
Y. Shiratori,
M. Omata,
M.E. Gershwin		 Autoimmune Liver Disease – Its Recent Advances: 141-147, 2000
Mucosal immunity and primary biliary cirrhosis: presence of antimitochondrial antibodies in urine A. Tanaka,
G. Nalbandian,
P.S.C. Leung,
G.D. Benson,
S. Munoz,
J.A. Findor,
A.D. Branch,
R.L. Coppel,
A.A. Ansari,
M.E. Gershwin		 Hepatology 32: 910-915, 2000

PubMed

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